Deep spatial proteomics
The department of immunodynamics aims to unravel the spatial mechanism regulating the crosstalk of immune cells with the surrounding tissue. Registration algorithms to combine multimodal imaging approaches, such as microscopy and mass spectrometry imaging (MSI), are developed (1). Artificial intelligence is used to deconvolute the data into tissue- and cell specific signals (2) for automated dissection by laser capture microdissection (LMD) (3) and high-sensitivity proteomics (4). Data analysis and integration are performed with python-based computing and automated via the snakemake workflow management (5).
Spatial Proteome Imaging
Detection of thousands of proteins, metabolites and lipids on tissue sections
Bioinformatics and pathway analysis
Analysis of multimodal and high-dimensional mass spectrometry datasets
